079 Glial fibrillary acidic protein (GFAP) astrocytopathy associated with cerebral micro-infarction and poor therapeutic response
نویسندگان
چکیده
منابع مشابه
Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients.
OBJECTIVE A novel autoimmune central nervous system (CNS) disorder with glial fibrillary acidic protein (GFAP)-IgG as biomarker was recently characterized. Here, 102 patients with GFAP-IgG positivity are described. METHODS The 102 included patients had: (1) serum, cerebrospinal fluid (CSF), or both that yielded a characteristic astrocytic pattern of mouse tissue immunostaining; (2) confirmati...
متن کاملAutoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids from Pug dogs with necrotizing meningoencephalitis.
Cerebrospinal fluids (CSFs) from 9 Pug dogs with necrotizing meningoencephalitis (NME: Pug dog encephalitis) were examined to identify the antigens for anti-astrocyte autoantibodies. Each CSF exhibited a positive reaction to the cytoplasm of cultured canine astrocytes by an indirect fluorescent antibody test. In an immunoblotting analysis on normal canine brain proteins, eight of 9 CSFs showed ...
متن کاملA New Splice Variant of Glial Fibrillary Acidic Protein, GFAP , Interacts with the Presenilin Proteins*
We describe a new human isoform, GFAP , of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAP mRNA is the result of alternative splicing and a new polyadenylation signal, and thus GFAP has a new C-terminal protein sequence. This provides GFAP with the capacity for specific binding of presenilin proteins in yeast and in vitro. Our observations suggest a direct link be...
متن کاملBlood Levels of Glial Fibrillary Acidic Protein (GFAP) in Patients with Neurological Diseases
BACKGROUND AND PURPOSE The brain-specific astroglial protein GFAP is a blood biomarker candidate indicative of intracerebral hemorrhage in patients with symptoms suspicious of acute stroke. Comparably little, however, is known about GFAP release in other neurological disorders. In order to identify potential "specificity gaps" of a future GFAP test used to diagnose intracerebral hemorrhage, we ...
متن کاملGlial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation.
Intermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a switch between vimentin and glial fibrillary acidic protein (GFAP) expression, with the latter being...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2019
ISSN: 0022-3050,1468-330X
DOI: 10.1136/jnnp-2019-anzan.67